Testolactona [Inn-Spanish]

Antineoplastic Agents, Hormonal

Testolactona [Inn-Spanish] Brand names, Testolactona [Inn-Spanish] Analogs

Testolactona [Inn-Spanish] Brand Names Mixture

No information avaliable

Testolactona [Inn-Spanish] Chemical_Formula

C₁₉H₂₄O₃

Testolactona [Inn-Spanish] RX_link

http://www.rxlist.com/cgi/generic2/testolactone.htm

Testolactona [Inn-Spanish] fda sheet

Testolactona_[Inn-Spanish] FDA

Testolactona [Inn-Spanish] msds (material safety sheet)

Testolactona_[Inn-Spanish] MSDS

Testolactona [Inn-Spanish] Synthesis Reference

No information avaliable

Testolactona [Inn-Spanish] Molecular Weight

300.392 g/mol

Testolactona [Inn-Spanish] Melting Point

218.5 ^oC

Testolactona [Inn-Spanish] H₂O Solubility

Slightly soluble (27.4 mg/L)

Testolactona [Inn-Spanish] State

Solid

Testolactona [Inn-Spanish] LogP

3.663

Testolactona [Inn-Spanish] Dosage Forms

For oral administration as tablets providing 50 mg testolactone per tablet

Testolactona [Inn-Spanish] Indication

For palliative treatment of advanced breast cancer in postmenopausal women.

Testolactona [Inn-Spanish] Pharmacology

Testolactone is a synthetic anti-neoplastic agent that is structurally distinct from the androgen steroid nucleus in possessing a six-membered lactone ring in place of the usual five-membered carbocyclic D-ring. Despite some similarity to testosterone, testolactone has no in vivo androgenic effect. No other hormonal effects have been reported in clinical studies in patients receiving testolactone.

Testolactona [Inn-Spanish] Absorption

Testolactone is well absorbed from the gastrointestinal tract.

Testolactona [Inn-Spanish] side effects and Toxicity

Oral LD₅₀s in mouse and dog are 1630 mg/kg and 593-926 mg/kg, respectively.

Testolactona [Inn-Spanish] Patient Information

Testolactona [Inn-Spanish] Organisms Affected

Humans and other mammals